Biotechnology
We use recombinant DNA technology and synthetic chemistry to develop proteins and peptides with applications in research, therapy, diagnostic and bioprocessing. Here is a general flow chart of our areas of actuation.
Analysis & Production
Peptides
Proteins
- Determine the structural identity and stability
- Use scalable recombinant production protocols (milligrams)
- Solid-phase synthesis (micrograms)
Research
Altincekic N., et al.
Front. Mol. Biosci., 2021.
VAZQUEZ, L. ; Lima, L.M.T.R. ; Almeida, M. S.
PLoS One, v. 12, p. e0182132, 2017.
Therapy
Formation of subvisible particles in commercial insulin formulations.
SILVA-JR, HAMILTON ; ARAÚJO, TALITA S. ; DA SILVA ALMEIDA, MARCIUS ; SCAPIN, SANDRA M.N. ; LUÍS MAURÍCIO, T.R.
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 216, 2022.
LIMA, LUÍS MAURÍCIO TR; DE ARAÚJO, TALITA STELLING; ALMEIDA, MARCIUS S. PEPTIDE SCIENCE, v. 113, 2021.
DE ARAÚJO, TALITA STELLING; SCAPIN, SANDRA MN; DE ANDRADE, WILLIAM; FASCIOTTI, MAÍRA; DE MAGALHÃES, MARIANA TQ; ALMEIDA, MARCIUS S; LIMA, LUÍS MAURÍCIO TR. BIOPHYSICAL CHEMISTRY, v. 1, p. 106554, 2021.
Monitoring asparaginase activity.
LIMA, LUÍS MAURÍCIO T R; ARAUJO, TALITA S; ALMEIDA, FÁBIO C L; ALMEIDA, MARCIUS S.
LANCET ONCOLOGY, v. 19, p. e574, 2018.
Ligand-free method to produce the anti-angiogenic recombinant Galectin-3 carbohydrate recognition domain.
WIECIKOWSKI, ADALGISA ; CABRAL, KATIA MARIA DOS SANTOS ; DA SILVA ALMEIDA, MARCIUS ; CARVALHO, RENATO SAMPAIO.
PROTEIN EXPRESSION AND PURIFICATION, v. 1, p. 1-2, 2017.
Bioprocessing
Properties of novel surfactin-derived biosurfactants obtained through solid-phase synthesis.
VAZQUEZ, LEONARDO ; TEIXEIRA DA SILVA FERREIRA, ANDRE ; CAVALCANTE, FERNANDA SAMPAIO ; GARCIA, ISRAEL JOSÉ P. ; DOS SANTOS, KATIA REGINA NETTO ; BARBOSA, LEANDRO AUGUSTO DE OLIVEIRA ; Almeida, Marcius da Silva ; MIGNACO, JULIO ALBERTO ; FONTES, CARLOS FREDERICO LEITE.
JOURNAL OF PEPTIDE SCIENCE, v. 1, p. e3129, 2018.